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Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - Dec 30, 2003
Applications Due:

Multiple Receipt Dates - See Link to Full Announcement for details.

total funding: Not Available
max award: none
min award: none
cost sharing, matching: No
number of awards: Not Available
type of funding: Grant

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),
through its Division of Kidney, Urologic and Hematologic Diseases and
Division of Digestive Diseases and Nutrition, invites experienced and new
investigators to submit research grant applications to pursue basic and
clinical investigations in order to better understand the pathogenesis,
natural history, therapy and prevention of hepatitis C in the setting of renal
disease or renal transplantation.

Hepatitis C, the most common cause of chronic liver disease in the United
States, is particularly common in the chronic renal disease patient
population. As hepatitis C is most effectively transmitted by percutaneous
exposure to infected blood, patients with chronic renal disease are at high
risk for acquiring the disease from transfusion of blood products or from
parenteral exposure to hepatitis C virus infection during hemodialysis
treatments. In addition to its frequent occurrence in patients with pre-
existing chronic renal disease, hepatitis C can induce an inflammatory
glomerular lesion in some infected patients without pre-existing renal
disease, which may cause chronic renal impairment. Patients with hepatitis C
and renal disease may develop serious and progressive chronic liver disease,
with its associated long-term morbidity and mortality from cirrhosis.

Although there have been major advances in the control and treatment of
hepatitis C in the general population, the incidence and prevalence of
hepatitis C in the dialysis patient population have not changed significantly
in the last decade. In the US dialysis patient population, the incidence of
hepatitis C has remained approximately 1-3% per year, while the prevalence
has remained approximately 8-10%. Hepatitis C is particularly difficult to
treat in patients with co-existing renal insufficiency, however, as therapy
of hepatitis C may indeed worsen renal disease or complicate management of
dialysis or renal transplant patients.

The natural history of hepatitis C in patients with chronic kidney disease or
in patients following renal transplantation has not been clearly defined.
Numerous reports suggest that hepatitis C infection is associated with a
significant worsening of patient survival on dialysis as well as following
renal transplantation. An understanding of the course of disease in such
patients is crucial, however, to developing indications for therapy and to
making recommendations for renal transplantation.

More effective means of prevention and therapy of hepatitis C in patients
with chronic kidney disease and following renal transplantation are clearly
needed. In view of the critical shortage of organs available for
transplantation, optimal safe strategies for use of kidneys from donors with
hepatitis C would also be of benefit.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Digestive Diseases and Nutrition Research
Kidney Diseases, Urology and Hematology Research

More Information:


If you have problems accessing the full announcement, please contact: NIH OER Webmaster

Address Info:

Office of Extramural Programs
6705 Rockledge Drive
Bethesda, MD 20892-7963

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